Mendeley
TY  _  JOUR
ID  -  2022100939658
TI  -  The Effect of Aerobic Training and Octopamine Supplement on Gene Expression Levels of VEGF and PDGFR in the Heart Tissue of Rats Exposed to Deep Fried Oil
JO  -   Journal of Sports Physiology and Athletic Conditioning
JA  -  ES
LA  -  en
SN  -  2783-3038
AU  -  Amoli Faegheh Jafari 
AU  -   
AU  -  Azarbayjani Mohammad Ali 
AU  -   
AD  -  گروه تربیت بدنی و علوم ورزشی، دانشگاه آزاد اسلامی واحد تهران شرق، تهران، ایران
AD  -  Department of Sports Physiology, Marvdasht Branch, Islamic Azad University, Marvdasht, Iran
AD  -  Department of Physical Education and Sport Sciences, CT.C., Islamic Azad University, Tehran, Iran	
AD  -  Department of Exercise Physiology, Sari Branch, Islamic Azad University, Sari, Iran
Y1  -  2023
PY  -  2023
VL  -  7
IS  -  
SP  -  1
EP  -  11
KW  -  Deep Fried Oils
KW  -   Aerobic Training
KW  -   Octopamine
KW  -   VEGF
KW  -   PDGFR.
DO  -  
N2  -  Background: Deep-fried oils (DFO) produce toxins that endanger people's health. Using herbal supplements along with exercise training can help improve health. The purpose of this study was to investigate the effect of aerobic training (T) and octopamine (O) supplementation on VEGF and PDGFR gene expression levels in the heart tissue of rats poisoned with DFO.
Materials and Methods: In this experimental study, 25 male Wistar rats were purchased and placed in 5 groups of 5 animals, including: 1) control, 2) DFO, 3) DFO+T, 4) DFO+O and 5) DFO+T+O.
Over a course of 4 weeks, rats in groups 2 to 5 received DFO by gavage, and rats in groups 3 and 5 ran on the treadmill 5 times a week with moderate intensity; also, rats in groups 4 and 5 received 81 μmol/kg octopamine supplement intraperitoneally 5 days a week. The Kolmogorov-Smirnov statistical test, independent samples t-test and two-way analysis of variance were used to analyze the research findings (p<0.05).
Results: DFO had a significant effect on increasing the gene expression levels of VEGF (p=0.001) and PDGFR (p=0.002); training had a significant effect on the reduction of VEGF (p=0.001) and PDGFR (p=0.012); also, octopamine consumption had a significant effect on the reduction of VEGF (p=0.001) and PDGFR (p=0.045).
Conclusion: It seems that aerobic training and octopamine consumption alone have anti-inflammatory effects in the heart tissue of DFO-poisoned rats, however they do not have significant anti-inflammatory interactive effects.

UR  - rimag.ir/en/Article/39658
L1  - rimag.ir/en/Article/Download/39658
ER  -  
