Mendeley
TY  _  JOUR
ID  -  2023010140644
TI  -  Effect of 8-week simultaneous metabolic resistance training and Chlorogenic acid supplement on the expression level of BMP2, BMP4, BMP6, and BMP7: A randomized open label clinical trial 
JO  -   Journal of Sports Physiology and Athletic Conditioning
JA  -  ES
LA  -  en
SN  -  2783-3038
AU  -  Takhty Maryam
AU  -   
AU  -   Soheili  Shahram 
AU  -  khosrow Ebrahim  khosrow Ebrahim 
AD  -  دانشجو دکترا
AD  -  نویسنده مقاله
AD  -  Assistant professor, Department of Physical education and sport science, Shahr-e-Qods Branch, Islamic Azad University, Tehran, Iran.
AD  -  Professor, Faculty of Sport Sciences and Health, Shahid Beheshti University, Tehran, Iran.
Y1  -  2023
PY  -  2023
VL  -  8
IS  -  
SP  -  44
EP  -  54
KW  -  metabolic resistance training
KW  -   green coffee
KW  -   obese and overweight women
KW  -   Bone/body morphogenic proteins
DO  -  
N2  -  Background: BMP has critical role in development, growth, and differentiation of cell. There is enough evidence regarding the role of BMPs in lipid accumulation and homeostasis The current study aimed to evaluate the simultaneous effect of eight weeks of metabolic resistance training (MRT) and Chlorogenic Acid (CGA) supplementation on expression level of BMP2, BMP4, BMP6, and BMP7 in overweight women.
Materials and Methods: We carried-out a randomized clinical trial performed on 40 overweight women in Iran 2020. We randomly assigned the study participants into four groups including combined 8-week course of metabolic resistance training (MRT) training and 400 mg chlorogenic acid (CGA) supplementation, 8-week course of MRT, CGA supplement, and the control group. Intervention included three MRT training sessions per week and the duration of each session was 45 minutes. The training exercise intervention was 10 minutes of warm-up, 30 minutes of metabolic resistance training, and 5 minutes of cool-down.  The supplementation arms were also received 400 mg / day CGA extracted from green coffee beans. Expression level of BMP2,4,6, and 7 was the main interested outcome that assessed pre and post intervention. 
Results: We observed significant decrease in BMP2 level in combined intervention group in compared with the control group (Regression coefficient= -2.7, 95% CI=-5.0, -0.4). Moreover, we observed that combined intervention has decreased BMP4 level and the observed difference was statistically significant (Regression coefficient= -6.2, -1.7, -10.6). No significant effect for MRT and CGA group was reported regarding BMP2, and BMP4. Neither combined nor separate form of CGA and MRT had no significant effect on BMP6 and BMP7 (P-value>0.05).  
Conclusion: Simultaneous MRT exercises and CGA supplementation prohibited expression levels of BMP2, and BMP4. However, they had no significant effect separately. There was no association between the interventions and expression level of BMP6, and BMP7. 



 Abstract 
Background and Objective: BMP has critical role in development, growth, and differentiation of cell. There is enough evidence regarding the role of BMPs in lipid accumulation and homeostasis The current study aimed to evaluate the simultaneous effect of eight weeks of metabolic resistance training (MRT) and Chlorogenic Acid (CGA) supplementation on expression level of BMP2, BMP4, BMP6, and BMP7 in overweight women.
Material and methods: We carried-out a randomized clinical trial performed on 40 overweight women in Iran 2020. We randomly assigned the study participants into four groups including combined 8-week course of metabolic resistance training (MRT) training and 400 mg chlorogenic acid (CGA) supplementation, 8-week course of MRT, CGA supplement, and the control group. Intervention included three MRT training sessions per week and the duration of each session was 45 minutes. The training exercise intervention was 10 minutes of warm-up, 30 minutes of metabolic resistance training, and 5 minutes of cool-down.  The supplementation arms were also received 400 mg / day CGA extracted from green coffee beans. Expression level of BMP2,4,6, and 7 was the main interested outcome that assessed pre and post intervention. 
Results: We observed significant decrease in BMP2 level in combined intervention group in compared with the control group (Regression coefficient= -2.7, 95% CI=-5.0, -0.4). Moreover, we observed that combined intervention has decreased BMP4 level and the observed difference was statistically significant (Regression coefficient= -6.2, -1.7, -10.6). No significant effect for MRT and CGA group was reported regarding BMP2, and BMP4. Neither combined nor separate form of CGA and MRT had no significant effect on BMP6 and BMP7 (P-value>0.05).  
Conclusion: Simultaneous MRT exercises and CGA supplementation prohibited expression levels of BMP2, and BMP4. However, they had no significant effect separately. There was no association between the interventions and expression level of BMP6, and BMP7. 



UR  - rimag.ir/en/Article/40644
L1  - rimag.ir/en/Article/Download/40644
ER  -  
