Mendeley TY _ JOUR ID - 2025010149044 TI - Nettle Supplementation Augments the Benefits of Combined Training on blood Glucose control and inflammatory factors in women with type 2 diabetes JO - Journal of Sports Physiology and Athletic Conditioning JA - ES LA - en SN - 2783-3038 AU - AU - dastah samaneh AD - دانشگاه مراغه AD - 1. Associate Professor of Exercise Physiology, Faculty of Sport Sciences, University of Maragheh, Maragheh, Iran Y1 - 2025 PY - 2025 VL - 15 IS - SP - 44 EP - 61 KW - Combined Training KW - Nettle Supplement KW - CTRP3 KW - IL-1β KW - IL-33 DO - N2 -

Background: Although consumption of nettle can change the inflammatory response in diabetic patients and may increase the benefits of exercise, no research has yet quantified the simultaneous effect of exercise and consumption of nettle on inflammatory indicators in diabetic patients. This research aims to investigate the effects of 12 weeks of combined training with nettle consumption on inflammatory factors in women with type 2 diabetes

Materials and Methods: The participants (N=60) were randomly distributed into four groups, each consisting of 15 participants: Combined Training group (Com), Nettle Supplement group (NS), Combined Training + Nettle Supplement (Com+NS), Control Group. The intervention comprised a 12-week treatment involving Nettle supplementation, a 12-week combined training (aerobic resistance-periodic) protocol with three sessions per week. Serum levels of blood glucose, insulin, HOMA-IR, CRPT3, IL-1β and IL-33 were measured within 48 h of the before and final training session.

Results: Statistical analyses revealed significant differences across all measures among the groups (p < 0.05). The combined training and supplementation approach led to notable reductions in blood glucose (p=0.001). Furthermore, CTRP3 and IL-33 levels in the three intervention groups were significantly increased compared to the control group (p=0.001). Also, there was a significant decrease in IL-1β levels in the Com, NS, and Com + NS groups relative to the control group (p=0.001).

Conclusion: This investigation underscores the potential of Nettle supplementation and Combined training as a synergistic strategy to ameliorate diabetes-related complications and enhance overall metabolic health in women with type 2 diabetes.

UR - rimag.ir/en/Article/49044 L1 - rimag.ir/en/Article/Download/49044 ER -