Mendeley TY _ JOUR ID - 2025032049796 TI - The effect of resistance training and testosterone consumption on Caspse3 gene expression in the heart tissue of male Wistar rats JO - Journal of Sports Physiology and Athletic Conditioning JA - ES LA - en SN - 2783-3038 AU - AU - Banaeifar َAbdolali AU - Arshadi Sajad AU - AD - دانشگاه آزاد اسلامی واحد تهران جنوب AD - Department of exercise physiology, STC, Islamic azad university, Tehran, Iran AD - Department of Exercise Physiology, South Tehran Branch, Islamic Azad University, Tehran, Iran AD - 3. Associated Professor of Exercise Physiology, Department of Sport Sciences, University of Zanjan, Zanjan, Iran. Y1 - 2025 PY - 2025 VL - 15 IS - SP - 1 EP - 10 KW - Resistance training KW - Caspase 3 KW - heart tissue KW - testosterone enanthate KW - Wistar rats DO - N2 -

Background: Studies show that cardiac tissue is one of the tissues that may be damaged as a result of anabolic steroid abuse. The aim of the present study was to study the effect of eight weeks of resistance training and testosterone consumption on the expression of caspase 3 under resistance training in the heart tissue of male Wistar rats.

Materials and Methods: In this study, 21 male Wistar rats (8 weeks old) with a mean weight of 252.20 ± 11.70 g were selected and divided into 3 groups: control, resistance training, and resistance training + testosterone. The resistance training protocol was performed five days a week (four sets of six with a rest of 60 to 90 seconds) in the form of climbing a 1-meter ladder, in which the weights were increased to 60% of the body weight in the first week and 20% of the rats' body weight each week. Testosterone enanthate injection was performed intramuscularly at a dose of 20 mg/kg, 3 days a week. To analyze the research findings, one-way analysis of variance test and Tukey's post hoc test were used to show the difference between groups (p≥0.05).

Results:

The results showed that the expression of caspase 3 in the exercise + testosterone group increased significantly compared to the control group (P=0.001). However, these changes in the exercise group did not show a significant difference compared to the control group (P≥0.05). Also, no significant change was observed between the two exercise and exercise + testosterone groups (P≥0.05).

Conclusion: Based on the results of the present study, it can be said that the use of supraphysiological doses of testosterone enanthate along with resistance training can increase apoptotic factors in the heart tissue of rats consuming enanthate and increase the possibility of myocardial damage.

UR - rimag.ir/en/Article/49796 L1 - rimag.ir/en/Article/Download/49796 ER -